Grasil Injection 100mg Amikacin Injection Uses side effects Dose In Pakistan In Urdu

GRASIL Injection 100mg Amikacin Injection Uses side effects Dose In Pakistan In Urdu

Grasil Amikacin 25mg Injection
Each ml contains:
Amikacin Sulphate USP
Amikacin  25mg
Grasil 250mg Injection
Each 2ml contains.
Amikacin Sulphate USP
Amikacin   250mg

Grasil 50mg Injection
Each 1ml contains:
Amikacin Sulphate USP
Amikacin  50mg
 Grsil 500mg Injection
Each 2m1 contains:
Amikacin Sulphate USP
Amikacin  500mg

Grasil 100mg Injection

Each 2mL contains:
Amikacin Sulphate USP
Amikacin 100mg

Grasil Injection 100mg INDICATIONS AND USAGE:

Amikacin sulphate injection is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.  Clinical studies have shown Amikacin sulphate injection to be effective in

  • bacterial septicemia (including neonatal sepsis)
  • in serious infections of the respiratory tract
  • bones and joints
  • central nervous system
  •  meningitis
  • skin and soft tissue
  • intra-abdominal infections (including peritonitis)
  • burns and post-operative infections (including post vascular surgery).
  • Clinical studies have shown amikacin also to be effective in serious complicated and
  • recurrent urinary tract infections due to these organisms.
  • Aminoglycosides including amikacin sulphate injection.
  • Grasil Injection is not indicated in uncomplicated initial episodes of urinary tract infections unless the causative organisms are not susceptible to antibiotics having less potential toxicity


Hypersensitivity to amikacin and aminoglycosides


Amikacin should be used with caution in patients with a history of

  • kidney diseases,
  • vertigo,
  • hearing loss.
  • myasthenia gravis,
  • parkinsonisms.
  • Use with Caution lo patients who are sensitive to aminoglycosides.
  • Perform monthly blood counts test for at least 4 months.
  • Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions.
  • Take appropriate measures in case of secondary infections
  • Category D. Grasil injection not given in Pregnancy
  • Nursing Mothers:
  • It is not known whether this drug is excreted in human milk.
  • As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk
  • Paediatric Use:
  • Aminoglycosides should be used with caution in premature and neonatal infants because of the renal immaturity of these patients and the resulting prolongation of serum half-life of these drugs Patients treated with aminoglycosides should be under dose clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. Safety for treatment periods which are longer than 14 days has not been established.

Amikacin Injection

Grasil Injection 100mg SIDE EFFECTS 

  • The severe or irreversible adverse effects of amikacin (sulphate), which give rise to further complications, including
  • nephrotoxicity,
  • neuromuscular blockade
  • renal tubular acidosis


Grasil Injection 100mg Drug Interactions:

  • Use of other nephrotoxic drugs
  • including other aminoglycosides, vancomycin,
  • some cephalosporins, ciclosporin, cisplatin and fludarabine, or of potentially ototoxic drugs such as ethacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity.  The neuromucu!ar blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids.

Grasil Injection 100mg DOSAGE:

  • The recommended dose for adults, children, and older infant with normal renal function is:
  • 15mg/kg/day in 2 or 3 equal doses administered at equally divided intervals;
  • i.e. 7.5mg/kg every 12 hours or 5mg/kg every 8 hours.
  • Treatment of patients with large body mass should not exceed 1.5g/day.
  • When amikacin S indicated in newborns, it is recommended that a loading dose of 10 mg/kg be administered initially to be followed with 7.5mg/kg every 12 hours
    Grasil Injection 100mg Duration of Treatment:
  • Duration of treatment depends on the seventy of the illness and on the clinical and biological course.
  • The usual duration of treatment is 7 to 10 days, it is desirable to limit the duration of treatment to short-term whenever feasible.
  • The total daily dose by all routes of administration should not exceed 15mg/kg/day

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