DYCLO (Diclofenac Sodium) PLUS INJ Uses Side effects, Dose , Contraindication

DYCLO Plus Injection – Diclofenac Sodium Uses Side effects, Dose , Contraindication

Dyclo Plus Injetion(Diclofenac sodium+ Lignocaine Hydrochloride)
Each 2ml ampoule contains:
Diclofenac Sodium B.P. …………….75mg
Lignocaine Hydrochloride B.P. …………2mg

DYCLO PLUS INJ (Diclofenac Sodium)  Uses Side effects, Dose , Contraindication

Diclofenac Sodium is a potent non- steroidal anti-inflammatory drug (NSAID) with marked analgesic and antipyretic properties. It also has some uricosuric effect. The actions of Diclofenac may inhibet the synthesis of prostaglandins by inhibiting cyclooxygenase, an enzyme that catalyzes the formation of prostaglandin precursors ( endoperoxides) from arachidonic acid.


It is 99.7% plasma protein bound and plasma half-life for the terminal elimination phase is 1-2 hours. It also enters the synovial fluid. Where maximum concentrations are measured 2-4 hours after the peak plasma values have been obtained. The apparent half-life for elimination from the synovial fluid is 3-6 hours.
Diclofenac is extensively metabolized to a range of phenolic compounds. About 60% of the administered dose is excreted via the kidneys in the form of metabolites and less than 1% in unchanged form. The remaining is excreted via the bile in metabolized form. Peak plasma concentration of diclofenac is achieved within half an hour following injections.


It is the most widely used local anaesthetic drug. Lignocain acts more rapidly and is more stable than most other local anaesthetics. It is a very useful surface anaesthetic. Like other local anaesthetic, lignocaine impairs the generation and conduction of the nerve impulses by slowing depolarization. Lignocaine is effectively absorbed from mucous membranes.
The onest of anaesthesia of lignocaine hydrochloride is more rapid and the duration of action is longer. A 1%-2% solution has duration of action of about 1-2 hours, blinding of lignocaine to plasma proteins is variable and concentration dependent. Approximately 90% of a parenteral dose of lignocaine is rapidly metabolized in the liver. Less than 10% of a dose is excreted unchanged in the urine.

DYCLO PLUS INJ – Diclofenac Sodium Uses Indications:

1) Rheumatoid Arthritis.
2) Osteoarthritis
3) Low back pain and other acute musculoskeletal disorders such as periarthritis (e.g Frozen shoulder), tendinitis, tenosynovitis, bursitis, sprains, strains and dislocations.
4) Ankylosing spondylitis.
5) Acute gout.
6) Acute trauma and fractures.
7) Control of pain and inflammation in orthopaedic, dental and other minor sugeries.
8) Juvenile chronic arthritis.
9) Postoperative pain.
10) Pain of renal colic.

DYCLO PLUS injection also contains lignocaine. It  Use as a local, therefore, the Reduced the pain at the injection site, which is most likely to occur after intramuscular injection of normal diclofenac Sodium.

DYCLO (Diclofenac Sodium) PLUS INJ


  • Dyclo(Diclofenac sodium)
  • Adults: one ampoule once ( or in severe cases, twice) daily by intramuscular injection.
  • Renal colic: one ampoule once daily intramuscularly, a further ampoule may be Give after 30 minutes, if necessary.

       The recommended maximum daily dose of diclofenac and lignocaine is 150mg and 200mg                      respectively by any route.

  • Chlidren: In juvenile chronic arthritis, 1-3mg of diclofenac/kg body weight daily in divided doses.
  •  Old age patients, the lowest effective dosage is recommended, Lowest Dose Or Bodyweight with age and physical status as Advise by the physician.

DYCLO Plus INJection Contraindications:

  • Hypersensitivity .
  • Dyclo Plus inj – diclofenac  SodiumNot Given in those patients From local anaesthetics of the Like amide type, although this type of cases is very rare.

DYCLO PLUS Injection – Diclofenac Sodium Side effects:

Side effects to diclofenac and lignocaine injection are usually mild and transient. However, if serious side-effects occur, the injection should be discontinued.

  • Gastrointestinal discomfort
  •  nausea
  • diarrhea
  • and occasionally bleeding may occur.

In very rare instances, injection site disorders may occur. In isolated cases, abscesses and local necrosis may occur. The adverse effects due to lignocaine mainly involve the CNS, are usually of short duration and are dose related.

CNs side effects

  • drowsiness,
  • dizziness,
  • disorientation,
  • confusion,
  • lightheadedness etc.


Dyclo Plus Injection (Diclofenac sodium) History of gastrointestinal ulceration, haematemesis or melaen, ulcerative colitis, Crohn’s disease, bleeding diathesis or hematological abnormalities. Patients with severe hepatic, cardiac or renal insufficiency or the elderly should be kept under close surveillance. All patients who are receiving long term treatment with non-steroidal anti-inflammatory agents  (e.g renal,hepatic function and blood counts

Use in pregnancy and lactation:

Dyclo should not be Doctor advice during pregnancy and lactation. 

ڈئیکلو پلس انجکشن میں دو فارمولے پائے جاتے ہیں ایک اس میں
لیگنوکین — 2ملی گرام
دوسرا ڈکلوفینک سوڈیم– 75ملی گرام
دئیکلو پلس انجکشن مختلف بیماریوں میں استعمال کیا جاتا ہے
ریوماٹائیڈ آرتھرائیٹس
پٹھوں کے درد
گردوں کے درد
ہڈیوں کے درد فریکچر کی وجہ سے ہو یا کمزوری کی وجہ سے ہو
سر درد
کرانک آرتھرائٹس
اپریشن کے بعد درد میں
ڈیلوری کے بعد درد میں
ایکسیڈنٹ کے بعد تکلیف میں مفید ہے
گوؤٹ یا گھٹیہ

ڈئیکلوپلس انجکشن کے مضر اثرات

متلی آسکتی ہے
اُلٹیاں آسکتی ہے
بد ہضمی ہو سکتی ہے
سر درد ہو سکتاہے
دست لگ سکتے ہیں
سر چکراسکتا ہے
غنودگی طاری ہو سکتی ہے
بے چینی ہو سکتی ہے

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