Cefiget Syrup USES SIDE-EFFECTS DOSE INTERACTION
1. CEFIGET Powder for Oral Suspension 100mg/5mL
Each 5mL of reconstituted suspension contains:
Cefixime trihydrate equivalent to Cefixime USP.…100mg
2. DS Powder for Oral Suspension 200mg/5mL
Each 5mL of reconstituted suspension contains:
Cefixime trihydrate equivalent to Cefixime USP.…200mg
The drug CEFIGET (Cefixime) is prescribed for the treatment of the following infections that are caused by susceptible strains identified microorganisms: – Uncomplicated urinary tract infections Otitis media Pharyngitis and tonsillitis acute exacerbations and acute bronchitis of chronic bronchitis gonorrhea (cervical/urethral)
DOSAGE and Administration
Adults and children older than 10 years old: The recommended dose for adults of CEFIGET (Cefixime) is 200- 400mg per day based on the severity of the infection. It can be administered as an individual dose or in two doses. Infections that are uncomplicated in the cervical/urethral gonor In the treatment of non-complicated cervical/urethral gonococcal infections, only a single oral dose of up to 400mg is suggested.
Children are advised to take 8 mg/kg/day in the suspension. It can be given in a single dose daily or it could be administered in two doses divided at 4 mg/kg for 12 hours with the exception of urinary tract infections in which a single dose per day must be administered. As a general guideline to prescribe for children, the following doses are for daily use in terms of the volume of their oral suspension. Please read carefully before using it.
This insert is regularly modified from time to time. Made by Opal Laboratories (Pvt.) Ltd., LC-41, L.I.T.E., Landhi, Karachi, Pakistan. For: recommended 6 months up one year 3.75mL every day Children aged 1-4: 5mL per day Children 5-10 years: 10mL per day Children with a weight of greater than 50kg and older than 10 years old should be treated using the dosage for adults that is recommended (200 up to 400 mg per day according to the severity of infection).
Cefiget Syrup USES Otitis Media:
Otitis media is best treated using suspension. Time of Treatment The standard course of treatment is seven days. The treatment can continue up to 14 days in the event of need. When treating diseases caused by S. Pyogenes an appropriate dose of CEFIGET (Cefixime) must be administered for a minimum of 10 days. Special groups Renal Insufficiency (Cefixime) is a treatment option when there is impairment of renal function.
A normal dose and schedule could be prescribed to patients with creatinine clearances of 20mL/min and higher. If the creatinine clearances are lower than 20mL/min, it’s advised to take a dose of 200mg every day should not be over. The dosage and treatment schedule for patients kept on chronic ambulatory dialysis or hemodialysis must be based on the same guidelines as for patients who have clearances for creatinine lower than 20mL/min. Instructions for making oral Suspension Then, fill the previously boiling and chilled water to the point on the bottle, then shake vigorously. After reconstitution, the suspension can be stored for up to 14 days at room temperature or even in the refrigerator, without the loss of any potency. Securely seal the container. Shake well before use. The remaining portion should be discarded at the end of 14 days.
CEFIGET SYRUP SIDE EFFECTS:
Cefixime is generally well-tolerated and the side effects are typically short-lived.
- Diarrhea (if severe diarrhea occurs, cefixime should be discontinued), changes in the color of stool,
- abdominal pain,
- and flatulence has been reported. Pseudomembranous colitis has also been reported.
- Central nervous system disturbance:
- Hepatic disorders:
- transient rises of liver transaminases, alkaline phosphatase,
- and jaundice is also possible.
- Other hypersensitivity reactions that typically subside after discontinuation of treatment;
- rare and irreversible hematological disorders;
- elevation in serum amylase. An increase in the prothrombin time has been observed in a small number of patients.
- Other reactions that could be a result include vaginitis and genital pruritus.
Cefiget Syrup USES CONTRAINDICATIONS :
Cefixime is not advised for patients who are hypersensitive to any ingredient in this medication. Patients who have a known allergy to the cephalosporin family of antibiotics. For children younger than six months of age as the effectiveness and safety of cefixime in these patients have not been proven.
AVOIDANCES THESE POEPLE
Cephalosporins are to be administered with caution to patients who are penicillin sensitive because there is evidence of cross-allergenicity in part between penicillins and the cephalosporins. Cefixime – Cefixime should be given with caution to patients suffering from severe impairment in renal function.
The use of wide-spectrum antibiotics can alter the colon’s normal flora and could lead to an increase in Clostridia. Pseudomembranous Colitis is a result of the use of broad-spectrum antibiotics (including macrolides semi-synthetic penicillins and cephalosporins) It is essential to be aware of its presence when patients experience diarrhea due to the treatment with antibiotics. It is possible for pseudomembranous symptoms to be present during or following the treatment with antibiotics. Broad-spectrum antibiotics like cefixime must be used with caution for patients with a history of digestive disease and colitis in particular.
Cefiget Syrup USES IN PREGNANCY
Don’t use cefixime in the treatment of S. aureus because the staphylococcus strain that is used is intolerant to cefixime. Pregnancy There is no evidence of research studies that are well-controlled and adequate in pregnant women.
Cefixime is not employed during pregnancy unless it is considered necessary by a physician. In nursing mothers, It isn’t established whether cefixime is excreted from human milk. It is recommended to consider stopping nursing for a short period while taking this medication.
Cefiget Syrup USES Anticoagulants and Drug Interactions:
It is recommended to exercise caution when patients are taking anticoagulants in conjunction with cefixime because cefixime could increase the prothrombin duration. Carbamazepine: Increased levels of carbamazepine have been reported, when cefixime is given concurrently. Drug monitoring could aid in detecting changes in the plasma concentrations of carbamazepine. Lab/Drug Interactions – A false positive reaction for ketones found in urine can occur when using tests that use nitroprusside, but not with tests that use Nitroferricyanide.
A false-positive reaction to glucose in the urine can be observed with Benedict’s or Fehling’s solutions, or with test tablets containing copper sulfate however not with tests that are based on the enzymatic reaction of glucose oxidase. The false positive of the Coombs test was documented in the course of treatment with cephalosporin antibiotics. Therefore, it must be noted that the positive Coombs test could be caused by the drug.
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